6. Epigenomics

Epigenomics (ChIP/ATAC/DNAme)

Metabolic switch memory & reversible chromatin states

Hibernation Focus: PPARα promoter methylation dynamics, H3K27me3 bivalent states, chromatin accessibility at lipid metabolism genes during entrance vs arousal
1
Peak/DMR Calling
MACS2 DiffBind methylKit
2
TF Footprinting
HINT-ATAC PPAR/FOXO HIF1A
3
Epigenetic-Transcriptome Link
Chrom Switch ATAC vs RNA Pdk4 Locus
4
Seasonal Memory
DNAme Trajectory Reversible Marks Next Season