Hibernation Omics Analysis Workflows

Interactive visualization pipelines for seasonal metabolic reprogramming research.
From sequence alignment to multi-omics integration, specialized for torpor-arousal cycles.

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9. Multi-omics Integration

Multi-omics Integration

Epigenome-Microbiome-Metabolome-Transcriptome causal networks

System-level Understanding: MOFA+ latent factor extraction, Bayesian causal inference (microbiome→SCFA→host gene), dynamic ODE modeling of entrance kinetics
1
Data Harmonization
MOFA+ Latent Factors Seasonal Variance
2
Cross-omics Correlation
sPLS Sparse PLS Multi-block
3
Causal Inference
Bayesian Net Microbiome→Host Mediation Analysis
4
Dynamic Modeling
ODE Models Entrance Kinetics Predictive Sim
5
System Map Visualization
Circos Pathway Map Ketone Flux
Recommended Tools
Factor Heatmap Correlation Scatter Causal Flow Dynamic Trajectory System Network