Hibernation Omics Analysis Workflows

Interactive visualization pipelines for seasonal metabolic reprogramming research.
From sequence alignment to multi-omics integration, specialized for torpor-arousal cycles.

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2. Bulk RNA-seq

Bulk RNA-seq

Seasonal transcriptional reprogramming & metabolic switching

Hibernation Focus: Time-series DEG analysis across torpor-arousal cycles, circadian rhythm disruption, cold-inducible RNA binding proteins
1
Batch Correction & QC
ComBat-seq RIN > 7 Seasonal Factor
2
Time-series DEG Analysis
MASTS/Limma 5 Stages Trend Clustering
3
Rhythmicity & Pathway
Cosinor GSEA OXPHOS Score
4
Cross-tissue Integration
Circos Liver-Brain Axis Ketone Metabolism
Recommended Tools
ComplexHeatmap GSEA Plot Circos Boxplot Volcano Plot Venn Diagram